Since the reform and opening-up policy, China’s foreign policy toward the United States has hoped to keep good relations with the United States. After the rise of China, China’s foreign behavior has become more aggressive and tough. In 2021, it is the centenary of the Communist Party of China. President Xi Jin-ping promised the CPC will lead China to fulfill the Chinese Dream of national rejuvenation and achieve the goal of building a great modern socialist country in all respects. In the U.S.-China relations, President Xi hoped to keep the relations stable. However, he also stressed the spirit of fighting. At the same year, Joseph Biden became the president of the United States. President Biden identified China as a strategic competitor. The differences and conflicts between the China and United States are more obvious in many issues, including human rights, political regime, Hong Kong, Xinjiang, Taiwan, economy, military, South China sea, East China sea, cyber etc. The U.S.-China relation is a challenge of the China develops in the future.