Since the emergence of novel coronavirus pneumonia (COVID-19) in late 2019, the cumulative number of confirmed cases worldwide has exceeded 233 million by September 30, 2021, with more than 4.77 million deaths. This pandemic has had a tremendous economic and social impact on humanity, and there is no end in sight. Although vaccines have been introduced to strengthen human defenses against the virus and reduce severe illness and mortality rates, rapidly evolving viruses continue to threaten humanity. This chapter examines the impact of the outbreak and the adaptation of countries in the Indo-Pacific region since the end of 2020, the recovery or stagnation of the industry in each country, and the responses of countries since the outbreak and the introduction of vaccines, including the progress of vaccine procurement and vaccination. Finally, this paper compares the order of the Indo-Pacific region before the outbreak with the current situation in the region and looks into the possible future development direction of the Indo-Pacific region.